The Loxonin S line of over-the-counter antipyretic analgesics provides fast, effective, and gentle relief from pain and fever.

Both formulations feature loxoprofen sodium hydrate, a clinically proven NSAID that suppresses prostaglandin production to alleviate inflammation, pain, and fever.

• Loxonin S Quick: Formulated with Quick Break Technology for rapid tablet disintegration and faster onset of relief.
• Loxonin S Premium: Enhanced with allylisopropylacetylurea and anhydrous caffeine for greater pain-relief efficacy and mental alertness, while magnesium aluminometasilicate protects the stomach.

Both variants are non-drowsy, easy to swallow, and designed for quick absorption with reduced gastric burden.

Features:

Relieves a wide range of pain and fever symptoms, including:

• Headache, menstrual cramps, toothache, sore throat, back pain, joint pain, neuralgia, muscle pain, shoulder stiffness, earache
• Pain from bruises, fractures, sprains, or injuries
• Reduces fever and chills associated with illness

Active Ingredients

Loxonin S Quick (per tablet)

• Loxoprofen Sodium Hydrate – 68.1 mg (equivalent to 60 mg anhydrous)
• Magnesium Aluminometasilicate – 100 mg (stomach protectant)
• Excipients: Calcium hydrogen phosphate, lactose, croscarmellose sodium, hydroxypropyl cellulose, magnesium stearate

Loxonin S Premium (per 2 tablets)

• Loxoprofen Sodium Hydrate – 68.1 mg (equivalent to 60 mg anhydrous)
• Allylisopropylacetylurea – 60 mg (enhances analgesic efficacy)
• Anhydrous Caffeine – 50 mg (supports pain relief and alertness)
• Magnesium Aluminometasilicate – 100 mg (stomach protection)
• Excipients: Lactose, cellulose, hydroxypropyl cellulose, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide, talc, ferric oxide, carnauba wax

Dosage and Administration

Age	Dose	Frequency	Instructions
Adults (15 years and older)	Quick: 1 tablet / Premium: 2 tablets	Up to 2 times daily (a third dose may be taken if symptoms recur)	Take with water or lukewarm water, avoiding empty stomachs. Maintain at least 4 hours between doses.
Under 15 years	—	Do not use	—

Do not exceed recommended dosage. Do not take continuously for more than 3–5 days without medical advice.

Warnings and Precautions

Do Not Use If:

• You have a history of allergic reaction to this product or other pain relievers.
• You have experienced asthma induced by analgesics or cold medicine.
• You are under 15 years old or within 12 weeks of expected delivery.
• You are being treated for stomach or duodenal ulcers, liver disease, kidney disease, or heart disease.
• You have been diagnosed with anemia, low platelet count, or other blood disorders.

Avoid using with other pain relievers, cold medicines, sedatives, or motion-sickness drugs.
Avoid alcohol before and after use.
Do not drive or operate machinery after taking Loxonin S Premium (may cause drowsiness).

Possible Side Effects

Stop use immediately and consult a doctor if you experience:

• Allergic reactions (rash, swelling, breathing difficulty)
• Digestive issues (abdominal pain, nausea, black/tarry stool, vomiting blood)
• Severe fatigue, dizziness, or swelling
  Rare but serious reactions may include Stevens-Johnson syndrome, liver/kidney impairment, or anaphylaxis.

Storage and Handling

• Store in a cool, dry place away from direct sunlight and humidity.
• Keep out of reach of children.
• Do not transfer contents to another container.
• Do not use past the expiration date.

Product Information

• Type: Non-prescription Antipyretic Analgesic (OTC, Japan)
• Form: Film-coated tablets (Loxonin S Quick / Premium)
• Contents: 12 tablets per package
• Manufacturer: Daiichi Sankyo Healthcare Co., Ltd.
• Category: Non-drowsy NSAID pain & fever relief